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Chaperone Code Program

Full Symposia Schedules and Abstracts 

Thursday October 26, 2023

2-4pm: Registration Open

5pm: Welcome address by Mark Woodford

Dimitra Bourboulia introducing Keynote Lecture by

Johannes Buchner (Technical University of Munich, Germany)

“A code of conformational switching in Hsp90”

6pm: Dinner


Friday October 27, 2023

7:30-9:00am: Breakfast

9:00-11:00am: Session 1: Determinants of Hsp90 function. 

Chair: Mark Woodford and Adrienne Edkins

9:00am     Jill Johnson (University of Idaho, USA) "The conformational code of Hsp90 impacts Hsp90 activity"

9:15am      Paul LaPointe (University of Alberta, Canada) "Ordered ATP hydrolysis is in the Hsp90 dimer is regulated by Aha1 and a conserved post-translational modification"         

9:30am     Andrea Rasola (University of Padova, Italy) "The chaperone code of TRAP1"

9:45am     Q&A

9:55am    Walid Houry (University of Toronto, Canada) "The Role of the Hsp90-R2TP Chaperone Complex in Ciliogenesis"

10:10am     Chris Prodromou (University of Sussex, UK) "The Crystal Structure of the Hsp90-LA1011 Complex and the Mechanism by which LA1011 may Improve the Prognosis of Alzheimer's Disease."

10:25am     Dan Gewirth (University at Buffalo, USA) "The effects of site specific N-glycosylation on Grp94 structure and function"

10:40am     Sarah Backe (State University of New York, USA) "The Hsp90 chaperone code regulates autophagy"

10:55am     Q&A

11:05am  Flash Talks: Pietro Poggio (University of Turin), Francesca Zuppini (University of Turin), Gianna Mochi (State University of New York)

11:25am   Sponsor Presentation: Sino Biological

11:40am   Sponsor Presentation: Nicoya

12:00-1:00pm: Lunch

1:00-3:30pm: Session 2: Targeting Hsp90 Chaperone Complexes. 

Chair: Mehdi Mollapour and Fortunate Mokoena

1:00pm   Brian Blagg (Notre Dame University, USA) "The design and development of isoform-selective inhibitors of Hsp90"

1:15pm    Giorgio Colombo (University of Pavia, Italy) "Deciphering the Hsp90 code with biocomputing"

1:30pm   Byoung Heon Kang (Ulsan National Institute, South Korea) "Targeting TRAP1 in the tumor microenvironment: inhibitors and breast cancer treatment."

1:45pm    Mark Woodford (State University of New York, USA) "The mitochondrial chaperone code drives pro-survival signaling in renal cell carcinoma"    

2:00pm     Q&A

2:10pm    Ioannis Gelis (University of South Florida, USA) "Co-chaperone targeted Hsp90 phosphorylation during kinase processing"    

2:25pm   Maria Theodoraki (Arcadia University) "Investigating the effects of DAP-19, a novel Hsp90β inhibitor, on breast cancer cell lines"

2:40pm    Rebecca Sager (State University of New York, USA) "Regulation of protein phosphatase 5 (PP5) activity and substrate release by SUMOylation" 

2:55pm   Q&A

3:05pm   Flash Talks: Katie Meluni (State University of New York), So-yeon Kim (UNIST), Nam Gu Yoon (UNIST), Vamsi Krishna Kommalapati (Augusta University)

3:30-3:45pm: Break


3:45-5:15pm: Session 3: Drivers of the Cell Stress Response.

Chair: Gary Jones and Andrew Truman

3:45pm    Lea Sistonen (Abo Akademi University, Finland), "Searching for HSF Interactomes"

4:00pm    Aimee Kao (UCSF, USA) "TSC1 as the molecular link between neurodevelopmental and neurodegenerative tauopathies"

4:15pm     Natasha Zachara (Johns Hopkins, USA), “The intersection between O-GlcNAc, AMPK, and Cytoprotection”

4:30pm    Richard Carpenter (Indiana University, USA) “Emerging roles for HSF1 in Breast Cancer”

4:45pm    Milad Alasady (Northwestern University, USA), "A JMJD6-HSF1-HSP feed forward circuit promotes cell adaptation to proteotoxic stress."

5:00pm    Q&A

5:10pm    Flash Talks: Jenny Pessa (Abo Akademi University), Sarah Rolli (Marquette University), Smriti Sangwan (UCSF)

6:00pm: Dinner

Saturday October 28, 2023

7:30-8:30am: Breakfast

8:30am    Special Presentation: Ilse Ariadna Valtierra Gutierrez (Senior Editor, Nature Communications)

8:45am-11:00am: Session 4: The Hsp70 Chaperone Code. 

Chair: Dimitra Bourboulia and Seema Mattoo

8:45am    Lila Gierasch (University of Massachusetts, Amherst, USA) "The Hsp70 Substrate-Binding Code"

9:00am    Len Neckers (NCI, USA) "Metabolism-Dependent PTMs –Lactylation of Specific Proteostasis Network Components"

9:15am     Andrew Truman (UNC Charlotte, USA) "Systematic analysis of Hsp70 phosphorylation using the chaperone code collection"

9:30am    Seema Mattoo (Purdue University, USA) "Manipulating AMPylation"

9:45am    Matthias Truttmann (University of Michigan, USA) "New insight into Hsp70 regulation by protein AMPylation"

10:00am  Amie Jo McClellan (Bennington College) "Exploring VHL as a model misfolded substrate for lysine-independent quality control" 

10:15am   Q&A         

10:30am  Flash Talks: Valeria Uvarova (UNC Charlotte), Siddhi Omkar (UNC Charlotte), Leon Tang Jia Wei (National University of Singapore), Asif Elahi (Augusta University), Duhita Mirikar (UNC Charlotte) 

11:00am   Special presentation on Cell Stress & Chaperones Journal 

11:30am     Winner of Best Flash Talks Announcement

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