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Chaperone Code Program

October 26, 2023

2-4pm: Registration Open

5pm: Welcome address by Mark Woodford

Dimitra Bourboulia introducing Keynote Lecture by

Johannes Buchner (Technical University of Munich, Germany)

“A code of conformational switching in Hsp90”

6pm: Dinner


October 27, 2023

7:30-8:30am: Breakfast

8:30-10:30am: Session 1: Determinants of Hsp90 function. 

Chair: Mark Woodford (State University of New York, USA)

8:30am      Dimitra Bourboulia (State University of New York, USA)

8:45am      Jill Johnson (University of Idaho, USA) "The conformational code of Hsp90 impacts Hsp90 activity"         

9:00am      Andrea Rasola (University of Padova, Italy) "The chaperone code of TRAP1"

9:15am       Walid Houry (University of Toronto, Canada) "The Role of the Hsp90-R2TP Chaperone Complex in Ciliogenesis"

9:30am      Chris Prodromou (University of Sussex, UK) "The Crystal Structure of the Hsp90-LA1011 Complex and the Mechanism by which LA1011 may Improve the Prognosis of Alzheimer's Disease."

9:45am      Dan Gewirth (University at Buffalo, USA) "The effects of site specific N-glycosylation on Grp94 structure and function"

10:00am    Sarah Backe (State University of New York, USA) "Activation of autophagy depends on Atg1/Ulk1-mediated phosphorylation and inhibition of the Hsp90 chaperone machinery"

10:15am Flash Talks

10:30-11:00am: Break

11am-12:45pm: Session 2: Targeting Hsp90 Chaperone Complexes. 

Chair: Dimitra Bourboulia (State University of New York, USA)

11:00am    Brian Blagg (Notre Dame University, USA) "The design and development of isoform-selective inhibitors of Hsp90"

11:15am     Giorgio Colombo (University of Pavia, Italy) "Deciphering the Hsp90 code with biocomputing"

11:30am    Byoung Heon Kang (Ulsan National Institute, South Korea) "Targeting TRAP1 in the tumor microenvironment: inhibitors and breast cancer treatment."

11:45am    Ioannis Gelis (University of South Florida, USA) "Co-chaperone targeted Hsp90 phosphorylation during kinase processing"

12:00pm   Paul LaPointe (University of Alberta, Canada) "Ordered ATP hydrolysis is in the Hsp90 dimer is regulated by Aha1 and a conserved post-translational modification"            

12:15pm    Maria Theodoraki (Arcadia University) "Investigating the effects of DAP-19, a novel Hsp90β inhibitor, on breast cancer cell lines"

12:30pm   Rebecca Sager (State University of New York, USA) "Regulation of protein phosphatase 5 (PP5) activity and substrate release by SUMOylation" 

12:45pm Flash Talks

1:15pm-2:30pm Lunch

October 28, 2023

7:30-9:00am: Breakfast

9:00am Special Session

10:00am-11:30am: Session 3: The Hsp70 Chaperone Code. 

Chair: Mehdi Mollapour (State University of New York, USA)

10:00am      Lila Gierasch (University of Massachusetts, Amherst, USA) "The Hsp70 Substrate-Binding Code"

10:15am       Len Neckers (National Cancer Institute, USA) "Metabolic regulation of the chaperone code – Lactylation of BiP"

10:30am      Andrew Truman (UNC Charlotte, USA) "Systematic analysis of Hsp70 phosphorylation using the chaperone code collection"

10:45am      Seema Mattoo (Purdue University, USA) - "Manipulating AMPylation"

11:00am       Matthias Truttmann (University of Michigan, USA)          

11:15am        Flash Talks

11:45-1:00pm Lunch

1:00-2:45pm: Session 4: Drivers of the Cell Stress Response. 

Chair: Gary Jones (Leeds Beckett University, UK)

1:00pm     Lea Sistonen (Abo Akademi University, Finland), "Searching for HSF Interactomes"

1:15pm      Aimee Kao (UCSF, USA) "TSC1 as the molecular link between neurodevelopmental and neurodegenerative tauopathies"

1:30pm     Natasha Zachara (Johns Hopkins, USA), “The intersection between O-GlcNAc, AMPK, and Cytoprotection”

1:45pm     Amie Jo McClellan (Bennington College) "Exploring VHL as a model misfolded substrate for lysine-independent quality control"

2:00pm     Richard Carpenter (Indiana University, USA) “Emerging roles for HSF1 in Breast Cancer”

2:15pm      Milad Alasady (Northwestern University, USA), "A JMJD6-HSF1-HSP feed forward circuit promotes cell adaptation to proteotoxic stress."

2:30-2:45pm Flash Talks

2:45pm Flash Talk Results Announcement

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